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    • PVA TePla America, LLC
    • 251 Corporate Terrace
      Corona, Ca 92879.

    Gas plasma technology is commonly used to precision clean and activate, decontaminate surfaces, promote adhesion of functional bio-molecules and in conjunction with specific chemical vapors sterilize in-vivo and in-vitro medical devices.

    PLASMA SURFACE TREATMENT OF BIOMATERIALS

    Acceleration of research and discovery in the biological science areas rely on advancing technologies in regenerative medicine, cellular, and bio-molecular isolation. Products and platforms such as tissue scaffolds, immunoassays, cell culture media, filtration and analyte delivery devices require plasma surface modification to enable selective bio-molecular immobilization and to avoid surface effects due to miniaturization. Newly developed micro-fluidic platforms used throughout multiple industries including the life science fields of drug discovery, diagnostics, medical device and drug delivery are significantly enhanced with plasma treatment. Micro-channels on clinical diagnostic devices are made “wettable” to fluids improving both flow and dispensing medical device surfaces that come in contact with biological environments such as the human body can be engineered to elicit specific biological responses, e.g. anti-fouling, anti-microbial, anti-thrombogenic etc. This can be achieved by direct use of plasma produced surfaces. Alternately plasma can be used to tailor surface chemistries with specific functional groups to act as a defined bio-molecule tie layer.

    Vascular grafts

    Expanded polytetrafluoroethylene (ePTFE) is a commonly used material for prosthetic implant applications. It’s mechanical strength, impermeability to blood and inertness

    Trauma Fixation

    Gas plasma precision cleaning, sterilization and surface activation of orthopedic implants promotes biocompatibility in a single, highly reproducible process step

    Tissue Scaffold

    NH3 plasma enhances cell affinity to porous polyactone scaffolds. Studies show cell seeding efficiency can be maintained above 99%, which is better than that achieved by prewetting with ethanol.

    Stents and Shunts

    For a lubricious coating to be effective on a medical device it must adhere to the substrate well enough that it doesn’t come off during usage. Herein lays the technology.

    Spinal implant

    Polyetheretherketone (PEEK) is a preferred material for vertebral implants due to its biocompatibility, physical properties, and above all its radiolucency. It is a semi-crystalline thermoplastic and therefore prone to absorption of cleaning solvents

    Pacemakers

    Plasma treatment of pacemakers and implantable cardioverter defibrillators ensures hermetically sealed devices and reliably bonded subcomponents

    Microfluidics

    The function of microfluidic devices are greatly enhanced by plasma. Microchannels on clinical diagnostic devices are made “wettable” to bio-fluids without having an effect on the properties of the analyte itself.

    Laboratory wear

    Materials used for laboratory containers (test tubes, vials, flasks, etc.) need to be chemically inert, shatter proof, non leachable, and most often require optical clarity. Glassware fulfills most of these criteria

    Joint Replacement

    Gas plasma precision cleaning, sterilization and surface activation of orthopedic implants promotes bio compatibility in a single, highly reproducible process step

    Intraocular Lens

    The replacement procedure of diseased or damaged natural eye lenses by artificial intraocular lenses (IOLs) requires an incision in the eye of just 2 – 3 millimeters. IOLs are manufactured using soft polymers

    Intraoccular delivery device

    Foldable intraocular lenses (IOL’s) can be implanted through <3mm incisions in the eye with the aid of an intraoccular delivery device. To assist in the mobility

    H202 Sterilization

    The increasing importance of infection control in life science industries is placing greater focus on sterilization technologies. New regulatory forces are generating industry specific criteria.

    Guidewires

    Lubricious coatings are best described as “slippery when wet” yet non-slippery when dry. They facilitate the insertion and manipulation of guide wires

    Defibrillators

    Artificial cardiac rhythm systems are complex devices with sub components requiring robust integration. Pacemakers and defibrillators are composed of electrode wires and sensors

    Decontamination

    When comparing the many different methods of sterilization, plasma sterilization has the distinct advantage in that it decontaminates as well. Decontamination means that the proteinacious

    Contact Lens

    Since the recent advent of silicone hydrogels, contact lenses can now be fabricated from a soft material with extremely high oxygen permeability. Unfortunately, hydrogels are also inherently

    Cell Cultureware

    Platforms for cell culture plates and cellular matrices are predominantly fabricated from synthetic polymers. While such materials are ideally inert, mechanically stable, and low cost for this industry

    Catheters

    PVA TePla’s low pressure or atmospheric plasma systems are used to improve wettability, bondability, printability and also to improve uniformity and lifetime of catheter coatings.

    Biosensors

    Gas plasma provides surface conditioning of in vitro diagnostic platforms prior to the deposition of the bio sensor materials. Conditioning may simply be precision cleaning of the substrate at the molecular level

    Biochemical Assays

    Microarray technology has accelerated the rate of biomolecular research by enabling an enormous number of experiments to be conducted in parallel. This is achieved by immobilizing arrays of probe biomolecules